@article {Nabatov2008,
	title = {{C-type lectin Mermaid inhibits dendritic cell mediated HIV-1 transmission to CD4+ T cells.}},
	journal = {Virology},
	volume = {378},
	number = {2},
	year = {2008},
	month = {sep},
	pages = {323{\textendash}8},
	publisher = {Elsevier Inc.},
	abstract = {Dendritic cells (DCs) are important in HIV-1 transmission; DCs capture invading HIV-1 through the interaction of the gp120 oligosaccharides with the C-type lectin DC-SIGN and migrate to the lymphoid tissues where HIV-1 is transmitted to T cells. Thus, the HIV-1 envelope glycoprotein gp120 is an attractive target to prevent interactions with DCs and subsequent viral transmission. Here, we have investigated whether the structural homologue of DC-SIGN, the nematode C-type lectin Mermaid can be used to prevent HIV-1 transmission by DCs. Our data demonstrate that Mermaid interacts with high mannose structures present on HIV-1 gp120 and thereby inhibits HIV-1 binding to DC-SIGN on DCs. Moreover, Mermaid inhibits DC-SIGN-mediated HIV-1 transmission from DC to T cells. We have identified Mermaid as a non-cytotoxic agent that shares the glycan specificity with DC-SIGN and inhibits DC-SIGN-gp120 interaction. The results are important for the anti-HIV-1 microbicide development directed at preventing DC-HIV-1 interactions.},
	keywords = {Animals, Anti-HIV Agents, Anti-HIV Agents: pharmacology, C-Type, C-Type: metabolism, CD4-Positive T-Lymphocytes, CD4-Positive T-Lymphocytes: virology, Cell Adhesion Molecules, Cell Adhesion Molecules: metabolism, Cell Line, Cell Surface, Cell Surface: metabolism, Cells, Cultured, Dendritic Cells, Dendritic Cells: virology, Helminth Proteins, Helminth Proteins: pharmacology, Helminth Proteins: toxicity, HIV Envelope Protein gp120, HIV Envelope Protein gp120: metabolism, HIV-1, HIV-1: drug effects, Humans, Lectins, Nematoda, Protein Binding, Receptors, Virus Attachment},
	issn = {1096-0341},
	doi = {10.1016/j.virol.2008.05.025},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/18597806},
	author = {Nabatov, Alexey a and de Jong, Marein a W P and de Witte, Lot and Bulgheresi, Silvia and Geijtenbeek, Teunis B H}
}
